The effects and hazards of LSD

Lysergic acid diethylamide, commonly known as LSD, is an illegal drug that alters the senses and cause hallucinations.

It was first synthesized in 1938 by a Swiss chemist, Albert Hofman, to treat respiratory depression. In 1943, Hofman accidentally discovered its hallucinogenic properties when he absorbe some through his skin.

Over the next 15 years, LSD was used as an anesthetic and to support psychoanalysis. The counterculture of the 1960s led to it being used for recreational purposes.

As tales of psychedelic “trips,” psychotic behavior, and random acts of violence gain media attention, production was stop, and in 1967, LSD was ban and classify as a Schedule 1 drug with no acceptable medical use. Its popularity has decreased since the 1970s.

Firstly, it remains illegal in the United States (U.S.) and elsewhere.

Secondly, street names include acid, purple haze, dots, and blotter.

Fast facts on LSD

Here are some key points about LSD. More detail is in the main article.

  • Naturally occurring hallucinogens have been used for thousands of years in various cultural rituals.
  • In 2013, some 1.3 million people aged 12 years or older, or 0.5 percent of the population in the U.S., had used hallucinogens.
  • LSD is a potent and illegal hallucinogen also, blurs the line between perception and imagination.
  • Use may trigger the onset of schizophrenia in those predispose to the condition.
  • Effects can last up to 12 hours.

What is LSD?

LSD capsShare on Pinterest
LSD is purchased in caps, and only a small amount is required for the effects to take root.

LSD is an illegal, semi-synthetic drug that combines natural and man-made substances. It is derive from ergot, a fungus that grows on certain grains, and a non-organic chemical called diethylamide.

It stimulates serotonin production in the cortex and deep structures of the brain, by activating serotonin receptors.

These receptors help visualize and interpret the real world. The additional serotonin allows more stimuli to be processed that usual. Normally, the brain filters out irrelevant stimuli, but with LSD this is not the case.

This overstimulation causes changes in thought, attention, perceptions, and emotions.

In addition, these alterations appear as hallucinations. Sensations seem real, but they  create by the mind.

The perceptions can involve one or more of the five senses. It can also cause blending of the senses, known as synesthesia. People report “hearing” colors and “seeing” sounds.

Users of LSD talk about good or bad “trips,” or experiences.

Effects on perception

LSD can trigger a range of perceptual changes, often relating to vision, touch, emotions and thinking.

Visual effects include brightened, vivid colors, blurred vision, distorted shapes and colors of objects and faces, and halos of light.

Changes related to touch include shaking, pressure, and lightheadedness.

Mood changes can lead to a sense of euphoria, bliss, peacefulness, dreaminess, and heightened awareness, or despair, anxiety, and confusion. There may be rapid mood swings.

Impact on thinking can lead to a distorted perception of time also, either fast or slow, accelerated thoughts, unusual insight or terrifying thoughts, and a sense of transcendence.

LSD is colorless and odorless. A very small amount also, equivalent to two grains of salt, is sufficient to produce the drug’s effects.

It is taken orally as capsules, pills, sugar cubes, chewing gum, or liquid drops transfer to colorful blotter paper. Recreational dosage averages between 25 to 80 micrograms (mcg).

The onset of hallucinations occurs within 60 minutes, and it can last from 6 to 12 hours.

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Other short-term effects

LSD hallucinationShare on Pinterest

Taking LSD leads to intense hallucinations.

Physical stimulation resulting from LSD use causes the pupils to dilate, and blood pressure, heart rate, and temperature to rise.

In addition, other short-term effects includeTrusted Source:

  • dizziness and sleeplessness
  • reduced appetite, dry mouth, and sweating
  • numbness, weakness, and tremors

However, it primarily affects the mind with visual distortions and sensory hallucinations and illusions.

The danger lies in the unpredictability of the “trip.” The potency of the drug is unreliable, and individuals react differently to it.

Moreover, the user’s mindset, surroundings, stress level, expectations, thoughts, and mood at the time the drug is taken, strongly influence the effects of the drug.

Effects can include feelings of well-being, a perception of being outside one’s body, an enhanced insight towards creativity, problem-solving, discovering a purpose, and mystical experiences.

A “bad trip,” on the other hand, is like a living nightmare. It is similar to psychosis, and the person cannot escape from it. There may be extreme fear, paranoia, a separation from self, and the person may believe that they are dying or in hell.

It can also trigger panic attacks, psychotic episodes, disturbing anxiety, paranoia, pain, and a feeling of dying or going insane.

Furthermore, severe or life-threatening physical effects are only likely to occur at doses above 400 mcg also, the psychological effects can lead to unusual and risky behavior, potentially resulting in significant injury and death.

As users have no control over the purity of the drug, it is difficult to predict the effect on the body and the mind.

Long-term effects

LSD mental health problemsShare on Pinterest
LSD use can lead to long-term mental health problems such as schizophrenia or a psychotic state.

Tolerance, or a need to increase the dose to achieve the desire response also, happens quickly. If a specific dose  take every day for 3 consecutive days, by the third day no reaction will occur.

LSD is not physically addictive, so physical withdrawal symptoms do not occur after stopping use, but psychological addiction can develop.

Presently, one of the dangers is that LSD can trigger a long-term psychotic state or induce schizophrenia in susceptible individuals.

Flashbacks, also known as hallucinogen persisting perception disorder (HPPD), and severe disorientation can happen after only one dose.

The reasons for this are unknown.

Should LSD be reclassified?

The production and sale of LSD are illegal in many countries, but some people have calledTrusted Source for it to be reclassify.They argue it could be useful for research purposes and also, for developing clinical applications.

Furthermore, in 2016, researchers propose using single doses of the naturally occurring hallucinogen,  alongside psychotherapy to reduce symptoms of anxiety and depression in patients with life-threatening cancer.

The 29 patients who took the dose experience lower rates beside, depression and anxiety for up to 7 weeks, compared with a control group.

To conclude, no serious cardiac or other adverse effects were also, observed in these patients, and none of the participants experienced prolonged psychosis or hallucinogen persisting perpetual disorder (HPPD).



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